Increased gluconeogenesis after subtotal pancreatectomy in the course cf persistent neonatal hypoglycemia

Laparascopic subtotal pancreatectomy in persistent hyperinsulinemic hypoglycemia of infancy

Two and half-year old Saudi boy was diagnosed with persistent hyperinsulinemic hypoglycemia of infancy (PHHI). He was initially managed with diazoxide and octreotide, however he was medical therapy unresponsive. Surgical intervention was recommended and he had laparoscopic subtotal pancreatectomy. This is the first reported Saudi case of PHHI who was managed surgically using the laparoscopic te...

Persistent Neonatal Hypoglycemia

Hypoglycemia is the most common metabolic alteration in neonatal period. Most of these neonates have transient hypoglycemia. However, persistent and recurrent hypoglycemia in neonates is usually caused by endocrine or metabolic disorders. These babies require frequent glucose monitoring to prevent hypoglycemic brain injury and advanced investigations for diagnosis of underlying etiology. An app...

Case report subtotal pancreatectomy as treatment for severe hypoglycemia after gastric bypass.

Persistent Hyperinsulinemic Hypoglycemia of Infancy: A Rare Case with Multiple Anomalies

Background: Few cases of persistent hyperinsulinemic hypoglycemia of infancy (PHHI) have been reported, so far. The main concern in the management of PHHI is to prevent severe hypoglycemia, which can lead to coma, brain damage and mental retardation. Total or subtotal pancreatectomy is normally required for the infants, despite the availability of medical therapies. Case report: In this report...

Sirolimus therapy following subtotal pancreatectomy in neonatal hyperinsulinemic hypoglycaemia: a case report

Hyperinsulinemic hypoglycaemia (HH) occurs due to an unregulated insulin production from the pancreatic b-cells in the presence of low blood glucose. Mutations in ABCC8 and KCNJ11 are associated with severe HH that is unresponsive to conventional medical treatment. The only treatment for patients with medically unresponsive diffuse HH is a subtotal pancreatectomy. However, following surgery, hy...